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Related post: SECTION Mucosal Immunity Section INSTITUTE AND LOCATION National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MP 20205 TOTAL MANYEARS: 1.0 PROFESSIONAL: .7 CHECK APPROPRIATE BOX(ES) □ (a) Human subjects □ (al) Minors □ (a2) Interviews □ (b) Human tissues KH (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed the space provided.) In this project we are exploring the cellular mechanisms involved in the differentiation of IgA B cells present in mucosal lymphoid nodules (Peyer's patches , PP) . In the first phase of this project we demonstrated that surface IgM (sIgM) -bearing B cells stimulated by the mitogen lipopolysaccharide (LPS) showed a high degree of Generic Artane differentiation into surface IgA(sIgA) -bearing B cells provided they were cultured in the presence of cloned T cells obtained from PP. In contrast, sIgM-bearing B cells stimulated by LPS in the absence of T cells or in the presence of cloned T cells obtained from spleen did not develop in slgA- bearing B cells. PP-derived cloned T cells had Purchase Artane thus brought about a class-spec- ific isotype switch, and could be designated IgA-specif ic switch T^ cells . Since the effect of the switch T cells obtained from PP was to induce PP B cells to become cells bearing surface IgA but not cells producing IgA for secre- tion, it was possible that additional T cell influence was necessary for termina!. differentiation- into IgA plasma cells. Accordingly, in the second phase of this project (accomplished during the past year) we conducted studies in which B cells were cultured sequentially, first with LPS and cloned switch T cells, and then with fresh uncloned Buy Artane Online T cells or T cell factors derived from the latter. In these studies we found that cells exposed in the first culture to PP cloned T cells (but not spleen cloned T cells) were induced to differentiate into IgA plasma cells in the second culture if the latter contained soluble factors derived from fresh T cells stimulated with Con Artane Tablets A or T cells themselves stimulated with staph protein A. In parallel experiments we found that cells exposed in the first cul- ture to spleen cloned T cells were induced to differentiate into IgG plasma cells in the second culture if the latter contained the same kinds of T cell influence^ as before. These studies show that IgA B cell differentiation is a two-step pro cess in which B cells Buy Artane are first induced to express Buy Cheap Artane surface IgA under the influen of switch T cells and they are then induced to differentiate into IgA plasma cells under the influence of helper T cells. PHS6040 (Rev. 1/83) 18-37 GPO 895-100 DEPARTMENT OF HEALTH AND HUMAN SERVICES - PUBLIC HEALTH SERVICE NOTICE OF INTRAMURAL RESEARCH PROJECT PROJECT NUMBER ZOI AI 00357-01 LCI PERIOD COVERED October 1, 1982 to September 30, 1983 TITLE OF PROJECT (80 characteri or leas. Title must fit on one line between the borders.) Studies of the Autologous Mixed Lymphocyte Reaction PRINCIPAL INVESTIGATOR (List other professional personnel on subsequent pages.) (Name, title, laboratory, and institute affiliation) Warren Strober, M.D., Chief, Mucosal Immunity Section, LCI/NIAID COOPERATING UNITS (if any) Gordon Yenokida, M.D., Staff Associate, Metabolism Branch, NCI, NIH LAB/BRANCH Laboratory of Clinical Investigation SECTION Mucosal Immunity Section INSTITUTE AND LOCATION National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MP 20205 TOTAL MANYEARS: 1.3 PROFESSIONAL. 1.3 CHECK APPROPRIATE BOX(ES) □ (a) Human subjects □ (a1) Minors □ (a2) Interviews ED (b) Human tissues □ (c) Neither SUMMARY OF WORK (Use standard unreduced type. Do not exceed the ipaee provided.) . This project concerns the study of the Artane 2 Mg autologous mixed lymphocyte reaction (AMLR), the proliferative response of T cells induced by exposure to autologous B cells or macrophages. In previous studies we have shown that l) the AMLR is re- duced in primary biliary cirrhosis (PBC), an autoimmune disease characterized by chronic hepatic Order Artane Online inflammation and biliary obstruction; 2) the AMLR results mainly in the proliferation of Order Artane T cells which can suppress pokeweed mitogen-driven Ig sy- thesis in_ vitro ; 3) the AMLR is augmented tenfold Artane Online if the stimulating autologous cellls (B cells) are pre-activated with EB virus or non-specific mitogens. These and other data suggest that the immunoregulatory abnormality found in PBC (in other autoimmune diseases) is due to the failure to generate suppressor T cells via the AMLR. To define further the T cells which react in the autologous MLR we have now established long term autoreactive T cell lines and have begun to define the func tion properties of cells Purchase Artane Online in such lines. These autoreactive T cell lines were gen erated by repeated stimulation of T cells with autologous non-T cells (B cells and macrophages), Artane Price in the presence of IL-2. The cells populations obtained re- spond to autologous cells but not to allogeneic cells; in addition, Artane 1 Mg they do not
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